Principles and processes for evaluating endocrine disruption in wildlife



Publisher: SETAC Press in Pensacola, FL

Written in English
Cover of: Principles and processes for evaluating endocrine disruption in wildlife |
Published: Pages: 491 Downloads: 876
Share This

Subjects:

  • Chemical elements -- Environmental aspects -- Congresses.,
  • Endocrine toxicology -- Congresses.

Edition Notes

Statementedited by R.J. Kendall ... [et al.].
SeriesSETAC technical publications series
ContributionsKendall, Ronald J., SETAC (Society)
Classifications
LC ClassificationsQH545.C47 P75 1998
The Physical Object
Paginationxxiv, 491 p. :
Number of Pages491
ID Numbers
Open LibraryOL684902M
ISBN 101880611171
LC Control Number97031743

  At the environmental level, wildlife is particularly vulnerable to the endocrine disrupting effects of pesticides, effects noted in invertebrates, reptiles, fish, birds and mammals were reviewed by Mnif et al., Many pesticides and industrial chemicals are capable of interfering with the proper function of estrogen, androgen and thyroid. Matter JM, Crain DA, Sills-McMurry C, Pickford DB, Rainwater TR, Reynolds KD, et al. Effects of endocrine-disrupting contaminants in reptiles: alligators. In: Kendall RD, Giesy J, Suk W, eds. Principles and Processes for Evaluating Endocrine Disruption in Wildlife. SETAC Pr., Pensacola, FL, ; R () not available: Book.   Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of s: 1. The Department of Environmental Toxicology (ENTX) is the academic home for the core faculty of The Institute of Environmental and Human Health (TIEHH) and the Institute for Forensic Science (IFS) at Texas Tech University. TIEHH and IFS provide faculty and graduate students opportunities for multidisciplinary research and scholarly engagement related to environmental, forensic and human .

As just one example, the U.S. EPA uses a scientifically validated screening process to identify chemicals that interact with the endocrine system (endocrine active chemicals). EPA requires validated scientific tests to be conducted to evaluate adverse health effects that occur when a chemical disrupts the endocrine system (endocrine disruptors. Principles for Identifying Endocrine-Active and Endocrine-Disrupting Chemicals The endocrine system is the collection of glands that produce hormones that help regulate many functions of the human body. Some natural and man-made chemicals can and do interact with the endocrine system, or are “endocrine-active.” In some cases, interaction. Endocrine principles, such as those outlined in this document, should be incorporated into programs by the EPA and other agencies charged with evaluating chemicals for endocrine-disrupting potential.   Nowadays, endocrine-disrupting chemicals are considered to be one of the main causes of the ever-increasing occurrence of problems with male fertility. These compounds of natural or anthropogenic origin are omnipresent in the environment and organisms are exposed to them practically nonstop through the air, water, food, and occupationally. Endocrine disruptors have the ability to .

evaluation of their role in endocrine disruption. The work reported in the last progress report includes a study carried out in on behalf of the Commission. The study identified a candidate list of substances, from which evidence of endocrine disruption or potential endocrine disruption was found for substances.   Endocrine principles, such as those outlined in this document, should be incorporated into programs by the U.S. Environmental Protection Agency (EPA) and other agencies charged with evaluating. Authored more than two hundred refereed journal and technical articles, and published or edited several books including, Toxic Substances in the Environment, Wildlife Toxicology, Wildlife Toxicology and Population Modeling: Integrated Studies of Agroecosystems, Principles, Principles and Processes for Evaluating Endocrine Disruption in Wildlife.   This book presents the relevant fundamentals of the endocrine systems of animals and humans, the toxicology, developmental toxicology, ecology, and risk assessment methods, and lays out the current state of understanding for the whole field, organized by the classes of compounds that have been identified as endocrine s: 2.

Principles and processes for evaluating endocrine disruption in wildlife Download PDF EPUB FB2

Endocrine disruption in wildlife has emerged as a significant factor in scientific debate about environmental policy. Using a risk-based approach, Principles and Processes for Evaluating Endocrine Disruption in Wildlife provides state-of-the-art information, principles, and processes for evaluating the effects of endocrine-disrupting chemicals in wildlife.

and by a book to be entitled Principles and Processes of Eval-uating Endocrine Disruption in Wildlife. Scientists who attend-ed this conference are developing book chapters that willinclude the plenary sessions, case studies, and the integration of toxi-cologic principles and processes, which will evolve into an ex-panded research agenda for Cited by: Todd Anderson, Environmental Toxicology of Munitions-Related Compounds, Wildlife Toxicology, /, (), ().

Crossref Changge Fang, Caiqiao Zhang, Huili Qiao, Guoliang Xia, Yaoxing Chen, Sexual difference in gonadal development of embryonic chickens after treatment of polychlorinated biphenyls, Chinese Science Bulletin Cited by: Principles and processes for evaluating endocrine disruption in wildlife.

Pensacola, FL: SETAC Press, © (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors / Contributors: Ronald J Kendall; SETAC (Society). Principles and processes for evaluating endocrine disruption in wildlife Principles and processes for evaluating endocrine disruption in wildlife Kendall, R.J.; Dickerson, R.L.

quired to evaluate cause and effect and potential impacts on survival and reproduction. The scientiï¬ c database on endocrine effects in wildlife is evolving. Abstract. The discovery that reproductive abnormalities are present in animals born in ecosystems polluted with chemicals known or suspected to have endocrine-disrupting effects may be considered a warning message from wildlife (1,2).Embryonic death, deformities, and abnormal nesting behavior have been observed in fish-eating birds residing in portions of the Great Lakes area where.

Based on the human and wildlife evidence, many scientists are concerned about chemical pollutants being able to interfere with the normal functioning of hormones, so-called endocrine-disrupting chemicals (EDCs), that could play a causative role in these diseases and disorders.

A Perspective on the Risk Assessment Process for Endocrine‐Disruptive Effects on Wildlife and Human Health * Robert J. Kavlock. Evaluating Endocrine Disruption In Vitro, In Vitro Toxicology Systems, /_13, (), Pesticides as Endocrine-Disrupting ChemicalsaaDisclaimer.

evaluating endocrine disruption in wildlife. Pensacola: SE- Principles and processes for evaluating endocrine disrup- Principles and processes for evaluating endocrine disruption in wildlife.

In book: Principles and Processes for Evaluating Endocrine Disruption in Wildlife (pp) Chapter: Effects of estrogenic compounds in reptiles: Turtles. ECETOC Compendium of test methods for environmental estrogens ECETOC, SETAC Workshop on principles and processes for evaluating endocrine disruption in wildlife Kendall et al., US Committee on the Environment Development of a national planning framework for endocrine disruptor research and Reiter et al.,   It provides principles and processes for evaluating the effects of endocrine-disrupting chemicals in wildlife.

It is written as a reference for educational purposes for environmental and industrial managers and planners in their decision-making involving endocrine-disrupting chemicals and protecting wildlife. Endocrine Disruptors in the Environment is an ideal book for environmental chemists and endocrine toxicologists, developmental biologists, endocrinologists, epidemiologists, environmental health scientists and advocates, and regulatory officials tasked with risk assessment in environment and health areas.

This brief paper summarises current knowledge concerning the effects of endocrine disrupting chemicals in wildlife, and indicates that, with a few exceptions, we do not yet have good evidence that endocrine disruption is causing serious effects at the population level.

The paper suggests that more field and semi-field studies are required to address this issue. This chapter outlines some of the principles on which regulation of endocrine disrupting chemicals (EDCs) depends, and provides an introduction to the concepts of hazard, weight of evidence and risk.

Challenges for the regulation of chemicals which act through endocrine mechanisms are discussed. Endocrine disruptors are found in many everyday products, including some plastic bottles and containers, liners of metal food cans, detergents, flame retardants, food, toys, cosmetics, and pesticides.

Some endocrine-disrupting chemicals are slow to break-down in the environment. That characteristic makes them potentially hazardous over time. Books: 1) Principles and Processes in Evaluating Endocrine Disruption in Wildlife, 2) Chemically Induced Alterations in Functional Development and Reproduction of Fishes.

Print this page. Tweet; Related. Smithsonian scientists compare environmental impacts of biofuels. BRIEFLY ( ).

Principles and Processes for Evaluating Endocrine Disruption in Wildlife. Society of Environmental Toxicology & Chemistry (SETAC) Press, Pensacola, FL., pp.

KENDALL, R.J. and T.E. Lacher, Jr., editors. Wildlife Toxicology and Population Modeling: Integrated Studies of Agroecosystems. Endocrine principles, such as those outlined in this document, should be incorporated into programs by the EPA and other agencies charged with evaluating chemicals for endocrine-disrupting potential.

State-of-the-art molecular and cellular techniques, and highly sensitive model systems, need to be built into current testing, in consultation. Endocrine-disrupting chemicals are able to mimic the actions of endogenous hormones and thus interfere with the endocrine systems that regulate development.

6,7 This disruption occurs at low doses presumed to be safe and within the range of exposure experienced by the general population (referred to as environmentally relevant doses 8,9); EDC. Patuxent Wildlife Research Center: Description: xxiv, Larger Work Type: Book: Larger Work Subtype: Other Government Series: Larger Work Title: Principles and Processes for Evaluating Endocrine Disruption in Wildlife: First page: Last page:.

Unfortunately, terms like ”endocrine disruptor” reveal only a small portion of the entire relevant literature. Further, there are political and economic interests in the avoidance of a label like ‘endocrine disruptor’ [, 21, ]; acknowledgement that a compound is an EDC would likely have unwanted consequences for its producer.

CHEM Trust has highlighted for nearly five years, that the current EU laws regulating the chemicals used in food contact materials (FCM) such as food packaging, cutlery, and factory equipment do not properly protect public materials, such as paper, card, inks and linings are not controlled by harmonised EU-level laws, and where harmonised laws exist, like e.g.

for plastic. Page address human and ecological (wildlife) effects; examine effects on estrogen, androgen, and thyroid hormone-related processes and on other hormones and their processes as more data and assays become available; and evaluate endocrine-disrupting properties of chemical substances and common mixtures.

EDSTAC estimates that approximat chemicals and mixtures will need to. Endocrine-disrupting chemicals (EDCs; also called xenobiotics) could disrupt natural systems in several ways. They may act by mimicking or inhibiting the actions of a hormone through interaction with its receptor and mechanism of action, by altering synthesis of a hormone or its receptor, or by altering the rate of metabolism and/or excretion.

Evaluation of carcinogenic substances from the environment is a challenge for scientists. mechanisms present in the human body will help us to come up with more solid conclusions regarding the direct effect of endocrine disruptors on a specific process, Soto AM, vom Saal FS, et al: Regulatory decisions on endocrine disrupting chemicals.

the endocrine system that are covered include the HPG, the HPT, and the HPA axes. This restriction is arbitrary and should not imply that endocrine disruptors cannot affect other endocrine axes. It is also emphasized that the general principles on which all endocrine (and probably paracrine) axes are first set up and then operate are essentially.

A risk-based field and laboratory approach to assess endocrine disruptions in wildlife. Author(s) Kendall, R.J.; Brouwer, A.; Giesy, J.P. Source: In: Principles and processes for evaluating endocrine disruption - p. 1 - Department(s) Sub-department of Toxicology: Publication type: Chapter in scientific book: Publication year: Comments.

many body processes, including growth and development, metabolism, and sexual differentiation. Some chemicals can mimic or block normal hormonal function in animals and humans. This can trigger a wide variety of responses. This process is called endocrine disruption.

Endocrine disruption in itself is not a toxic effect; rather it is a means by. In: Principles and Processes for Evaluating Endocrine Disruption in Wildlife (Kendall R J, Dickerson RL, Giesy JP, Suk WP, eds), Pensacola, FL:SETAC Press, ; () Purchase I. Ethical review of regulatory toxicology guidelines involving experiments on animals: the example of endocrine disrupters.

Evaluate endocrine disrupting properties of both chemical substances and common mixtures: The universe of chemicals to be prioritized for endocrine disruptor screening and testing numbers more t and includes those listed in the TSCA Inventory, active pesticide ingredients, and ingredients in cosmetics and food additives.Endocrine disruptors, sometimes also referred to as hormonally active agents, endocrine disrupting chemicals, or endocrine disrupting compounds are chemicals that can interfere with endocrine (or hormonal) disruptions can cause cancerous tumors, birth defects, and other developmental disorders.

Found in many household and industrial products, endocrine disruptors .Fish and wildlife as sentinels of environmental endocrine disruptors. pp In: “Principles and Processes for Evaluating Endocrine Disruption in Wildlife” (RJ Kendall, JP Giesy, RL Dickerson, and W Suk, eds.).

SETAC Press, Pensacola, FL.